4578 Early life stress promotes chronicity of experimental colitis
نویسندگان
چکیده
منابع مشابه
Histological Evaluation of Pancreas Following Early Life Stress in Exposure to Pubertal Stress in Male Rats
Background and purpose: Stressful events in early-life induce metabolic disorders in adolescence. The aim of this study was to investigate the effect of early-life stress on number or area of Langerhans islets in exposure to foot-shock and psychological stress in male rats. Materials and methods: The rats were divided into six groups: control (without stress), early-stress (stress at 2 weeks o...
متن کاملCellulose Supplementation Early in Life Ameliorates Colitis in Adult Mice
Decreased consumption of dietary fibers, such as cellulose, has been proposed to promote the emergence of inflammatory bowel diseases (IBD: Crohn disease [CD] and ulcerative colitis [UC]) where intestinal microbes are recognized to play an etiologic role. However, it is not known if transient fiber consumption during critical developmental periods may prevent consecutive intestinal inflammation...
متن کاملHVEM Signalling Promotes Colitis
BACKGROUND Tumor necrosis factor super family (TNFSF) members regulate important processes involved in cell proliferation, survival and differentiation and are therefore crucial for the balance between homeostasis and inflammatory responses. Several members of the TNFSF are closely associated with inflammatory bowel disease (IBD). Thus, they represent interesting new targets for therapeutic tre...
متن کاملMacrophage and T Cell Produced IL-10 Promotes Viral Chronicity
Chronic viral infections lead to CD8(+) T cell exhaustion, characterized by impaired cytokine secretion. Presence of the immune-regulatory cytokine IL-10 promotes chronicity of Lymphocytic Choriomeningitis Virus (LCMV) Clone 13 infection, while absence of IL-10/IL-10R signaling early during infection results in viral clearance and higher percentages and numbers of antiviral, cytokine producing ...
متن کاملchosocially Influenced Cancer: Diverse Early-Life Stress
nloaded s perspective on Boyd et al. (beginning on page 1398 in this issue of the journal) discusses recent hed research examining the interplay between social stress and breast cancer. Cross-disciplinary s using genetically defined mouse models and established neonatal and peripubertal paradigms ial stress are illuminating biological programming by diverse early-life experiences for the risk o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical and Translational Science
سال: 2020
ISSN: 2059-8661
DOI: 10.1017/cts.2020.65